TNFAIP6 and serum lipopolysaccharide activity: In addition, since the HA expression in liver sinusoidal vasculature is 500- and 600-fold higher than in the lung vasculature both at baseline and during endotoxemia [7], much higher levels of TSG-6 than those locally produced in ALI may be required to significantly modulate inflammation, including neutrophil trafficking across lung tissue barriers.