TNFAIP6 and Sepsis: Building on reports that TSG-6 mediated formation of HC-modified HA is critical to neutrophil sequestration in liver sinusoids [6, 7] and an important protective mediator of survival in lipopolysaccharide (LPS) models of sepsis [6, 8–10], we investigated the role of HC-HA in ALI induced by respiratory infections, modeled by LPS or bacteria.