Resected angiosarcoma tissue from the scalp was analyzed for gene mutations, and demonstrated KIT amplification (8 copies), KDR amplification (8 copies) (Fig. 2), RB1 codon 251 arginine mutated to a stop codon, and TP53 codon 195 isoleucine mutated to threonine with a reduced copy number. Here, KDR is linked to angiosarcoma.