The primary MANEC of the ileum showed two different tumor components: One gland-forming adenocarcinoma-component including PAS-positive mucins in the tumor cell cytoplasm or gland lumina as well as a solid tumor forming neuroendocrine carcinoma-component showing a strong and diffuse immunohistochemical positivity for synatophysin and to a lesser content chromogranin A as well (Fig. 1). The gene discussed is CHGA; the disease is neoplasm.