This observation implicated that although tumor cells could be primarily targeted by CTLs, EMT‐converted tumor cells with upregulated PD‐L1 expression make CTLs’ apoptosis through interaction between PD‐L1 and PD‐1.11, 12, 43 In this situation, EMT‐converted tumor cells could escape from the immune system including CTLs‐mediated lysis and reach the distant metastatic sites to establish new colonies. Here, CD274 is linked to neoplasm.