In CRC patients, the negative tumor PD-L1 expression in metastases (HR = 5.129 (95% CI: 1.567–16.791), P = 0.007) and high ratio of signet cells (HR = 4.655 (95% CI: 1.366–15.863), P = 0.014) were identified as potential prognostic factors (Table 2). Here, CD274 is linked to colorectal carcinoma.