Differences in the ability of cells to detect an RNA virus via TLRs 7 and 8 were also described for Zika virus (ZIKV) infection, as no TLR7 activation was detected in primary human fibroblasts [122], while genes implicated in TLR7 and TLR8 pathways were found to be upregulated in the human neural progenitor cells (hNPCs) infected with this virus [123]. This evidence concerns the gene TLR7 and Zika virus infectious disease.