Several compounds associated with AMD have been shown to activate the NLRP3 inflammasome, like the complement component C5a and AMD including drusen components including C1q and amyloid-β [3], the lipofuscin component N-retinylidene-N-retinyl-ethanolamine (A2E), and the lipid peroxidation product 4-hydroxynonenal (HNE) [10]. The gene discussed is NLRP3; the disease is age-related macular degeneration.