Shi et al. [181] recently demonstrated that the adoptive transfer of Treg cells protected the mice intraperitoneally challenged with CVB3 from myocarditis through the TGF-β–CAR (transforming growth factor β-coxsackie virus and adenovirus receptor) pathway, which maintained the antiviral immune response against CVB3 and thus suppressed the immune response to the cardiac tissue. The gene discussed is TGFB1; the disease is myocarditis.