Fifteen module-related DEGs were obtained, and melittin could constrain the expressions of LPAR1, COL5A1, and COL6A2 associated with the PI3K-Akt signaling pathway and CXCL1, CXCL2, and CXCL3 involved in the TNF signal pathway in BC cells. This evidence concerns the gene COL6A2 and breast cancer.