Jeong et al. probed that melittin could constrain EGF-induced MMP-9 expression via blocking the NF-κB and PI3K/Akt/mTOR signaling pathway and repress EGF-induced FAK phosphorylation through inhibiting the mTOR/p/0S6K/4E-BP1 signaling pathway in breast cancer cells [17]. This evidence concerns the gene AKT1 and breast cancer.