For a more efficient outcome, TLR agonists can be used in combination with non-TLR agonists, as demonstrated in a C57BL/6 mice tumor model in which HPV16 E7 vaccine was coadministrated with monophosphoryl lipid A (MPL), a TLR4 agonist, and α-galactosylceramide [7]. This evidence concerns the gene TLR4 and neoplasm.