Another case study from Japan found higher serum levels of soluble IL-2 receptor (IL-2R), IFN-γ, IL-1β, IL-6, IL-8, and granulocyte-macrophage colony stimulating factor in a BD-associated MDS patient with trisomy 8 during the active phase [28]. Here, CXCL8 is linked to myelodysplastic syndrome.