A meta-analysis of 12 clinical trials that recruited 1582 patients with sepsis found that serum NGAL was applicable for diagnosing sepsis-associated AKI in adults, with a sensitivity of 0.881 (95% CI, 0.819–0.923) and a specificity of 0.474 (95% CI, 0.367–0.582) [50]. Here, LCN2 is linked to acute kidney injury.