In a mouse model of sepsis, TIMP-2 and IGFBP7 were shown to predict the development of AKI, with an area under the receiver operating characteristic curve (AUC) of 0.76 and 0.72, respectively; the result for the [TIMP-2]·[IGFBP7] complex was 0.89 (95% CI, 0.80–0.98) [58]. This evidence concerns the gene TIMP2 and acute kidney injury.