A multicenter prospective study of 232 patients with sepsis at 39 ICUs in Europe and North America found that the urine test of [TIMP-2]·[IGFBP7] might accurately predict the development of AKI in septic patients, with an AUC of 0.84 (95% CI, 0.77–0.90) in the summary receiver operating characteristic analysis [59]. This evidence concerns the gene TIMP2 and Sepsis.