While a marginal increase (<1-fold, P > 0.05) in LNCaP STAT3 expression upon addition of C12-HSL was observed, a decrease (<1-fold) was noted in DU145 cells and RWPE1 cells which was not significant (P = 0.05). STAT1 mRNA expression was observed in WT RWPE1 and PCa cells. This evidence concerns the gene STAT3 and posterior cortical atrophy.