ICAM1 and asthma: Eosinophil-derived exosomes isolated from asthmatics may have both autocrine and paracrine functions as they increase in the production of chemokines, reactive oxygen species (ROS), and nitric oxide (NO) from target eosinophils as well as enhancing eosinophil migration by upregulating the expression of adhesion molecules such as intercellular adhesion molecule 1 (ICAM-1) and integrin α2 [49] which is a critical step in asthma development [15].