These include chemokines, lipid mediators, and cytotoxic granule proteins such as major basic protein (MBP), eosinophil peroxidase (EPX), eosinophil cationic protein (ECP), and eosinophil-derived neurotoxin (EDN), which together result in several key features of asthma. The gene discussed is RNASE3; the disease is asthma.