CDKN1A and central nervous system cancer: Gal-3 can increase cell growth of hepatocellular carcinoma [40], glioma cells [41], pancreatic cancer proliferation, The effects of Gal-3 on the cell proliferation and cycle came about as a result of the translocation ability of Gal-3 into the nucleus by binding with Impotin, Sufu, and Nup98, wherein it controls the cell cycle through the interaction with cyclin A, cyclin D, cyclin E, p21 (WAF1), and p27 (KIP1), accelerating cancer cell proliferation [42].