Faulty insulin signaling by virtue of mutations can both be used to model diabetes type 1 (ILPs loss-of-function mutations [23], and even explore genes regulating insulin secretion [199]), and also diabetes type 2, with loss-of-function mutations in the rest of the pathway, as the net effect would be insulin resistance [27, 31, 71]. This evidence concerns the gene INS and type 2 diabetes mellitus.