In one of the early studies [84] conducted using microarray profiling, a 13-miRNA signature distinguished (i) chronic lymphocytic patients exhibiting high expression of ZAP-70 (prognostic factor) from patients with low levels of ZAP-70 and (ii) between cases with mutated and unmutated IgVH. This evidence concerns the gene ZAP70 and B-cell chronic lymphocytic leukemia.