In hepatocellular carcinoma and HepG2 cell line, high expression levels of the KLF6-SV2 lead to a significant reduction in cell proliferation associated with apoptosis by activation of p21 (CIP/WAF1) and the proapoptotic Bax gene, mediated by the p53 [25]. The gene discussed is CDKN1A; the disease is hepatocellular carcinoma.