Across > 200 sarcoma patients within TCGA, those within the highest quintile for PKM2/PKM1 expression ratio had a significantly shorter median 5-year survival when compared to either those within the lowest quintile for PKM2/PKM1 expression ratio, or when compared with all other patients combined (Fig. 2a, Additional file 2: Figure S2). The gene discussed is PKM; the disease is sarcoma.