To investigate the role of PKM2 in sarcoma development in the KP model, we crossed mice with a conditional allele of Pkm2 (M2fl) [17] to KP mice and performed intramuscular infections of cohorts of KP M2fl/fl and KP M2+/+ mice with Ad-Cre (Fig. 3a). This evidence concerns the gene PKM and keratosis pilaris.