PLAU and neoplasm: The cross-talk between cancer cells and TAMs upregulates the secretion of MMPs, uPA/uPAR, and prostaglandin E2 (PGE2) [79, 80, 114–117] which influence tumor migration and invasion through activation of NFkB, the key regulator of pro-inflammatory molecules in both TAMs and cancer cells, making them even more important in tumor progression [79, 80].