PLAU and cancer: The propensity of OvCa to metastasize to the mesothelial cells is initially instigated by cancer cell secretome that preconditions the mesothelial cell niche to induce the expression of multiple pro-inflammatory mediators as bioactive lipids (e.g. LPA)/inflammatory cytokines/chemokines [78–80], ECM/integrins [67, 68, 81–86], cell adhesion molecules as VCAM1, ICAM1, CD44/HA [87–89], and uPA/uPAR [71, 90].