PLAU and cancer: The bidirectional cross-talk between cancer and mesothelial Cells promotes cancer cell chemotaxis to the mesothelial cells, followed by integrin-mediated adhesion and invasion with subsequent increase in MMPs, and urokinase type plasminogen activator (uPA) and its receptor (uPAR) [70–73]; eventually leading to mesothelial clearance and invasion of the sub-mesothelial layers [74–76].