An immunohistochemical analysis showed an obvious increase in staining for cleaved caspase 3, PUMA and p53, and an obvious decrease in the staining for p-MDM2 in the foretinib-treated tumors in ECC and HEC-108 cell tumor xenografts, indicating that foretinib induced apoptosis and p53 activation in ECC and HEC-108 cell tumor xenografts. Here, MDM2 is linked to neoplasm.