In this study, we have evaluated in a selected group of invasive breast carcinoma tumor specimens, Bcl6, p53 expression, apoptosis by TUNEL assay and caspase3 expression, macrophages, mast cells, and micro vessel density, to further clarify the crucial role played by epigenetic events and by the tumor microenvironment during breast cancer progression. The gene discussed is TP53; the disease is breast cancer.