Among these were two variants found in 1 of 16 (6%) samples, MYC, a heterozygous missense mutation (chr13:25203051, c.185C>T, p.Ser62Phe) with frequency of 40.9%, interestingly, existence of this variant corresponded to the Canine genome location (CanFam3.1) - chr13:25203051-25203052 and in the human genome location (hg38) - chr8:127738447-127738448 has been previously reported in cutaneous squamous cell carcinoma [25], however, frequency for the existence of this variant is unknown. The gene discussed is LGR5; the disease is cutaneous squamous cell carcinoma.