Similarly, Broutier et al. and Delloye-Bourgeois et al. have demonstrated anti-tumor effects in two aggressive subtypes of non-Hodgkin lymphoma and non-small cell lung cancer respectively through the interference of netrin-1 and its receptors in high netrin-1 expressing tumors [5, 15]. This evidence concerns the gene NTN1 and non-Hodgkin lymphoma.