NTN1 and renal cell carcinoma: In addition, qPCR confirmed a significant upregulation of NTN1 in sunitinib-conditioned RCC cell lines (CAKI-1 WT 1±0.040 vs DC2016.725±2.415; p=0.0029; CAKI-2 WT 1±0.0417 vs DC20 2.119±0.165; p= 0.0027 and ACHN WT 1±0.028 vs DC20 1.304±0.015; p=0.0007) (Figure 4B).