In addition to T-ALL, aberrant JAK/STAT signaling occurs in other hematological malignancies including myeloproliferative neoplasms (MPN) such as polycythemia vera [7], B-ALL [8, 9], acute myeloid leukemia (AML) [10, 11], and lymphoma [12, 13]. Here, SOAT1 is linked to acute myeloid leukemia.