In the other five tumors, SNVs were identified in one to three potential cancer driver genes: in tumor 413, RSBN1; in tumor 416: TTN and GRIN1; in tumor 401: SEMA6D [21, 22], as well as MTHFD2; in tumor 417: GRHL2, PRICKLE2 and NDST4. In tumor 404, a possible cancer driver is ELMO3, which KM plotter indicated that overexpression is associated with poor overall survival (Supplementary Figure 1). The gene discussed is MTHFD2; the disease is neoplasm.