MTHFD2 and cancer: Seven genes were relatively frequently mutated (≥1%) in cancer in general or in breast cancer specifically: CACNA1E, HECW2, STAB1, ZNF462, FLG, TTN and NDST4. Finally, using the above ranking system, 20 genes, scoring at least 2, were considered possible cancer drivers (Supplementary Tables 9, 9a), such as PIK3AP1, GRHL2, CACNA1E, SMURF2, SEMA6D, RSBN1, MTHFD2, among others.