HECW2 and cancer: In tumor 402, besides PIK3CA and CIITA, other candidate cancer genes harboring somatic SNVs were CACNA1E, NES, STAB1, HECW2, SMURF2 and ZNF462. In tumor 406, SNVs were detected in three known cancer genes reported in the “Cancer Gene Census” database [19]: PIK3CA, TP53 and PRKAR1A. However, the alteration detected in the latter was considered pathogenic in only one of the five mutation function assessment algorithms (Table 1).