Two patients presented more than one (missense) VUS in BRCA2 gene, one of them, diagnosed with a triple negative tumor reported a positive family history (c.3349A>G; c.5414A>G; c.8092G>A); the other one, diagnosed with a luminal B tumor, presented a limited family history (c.2837A>G; c.7418G>A). Here, BRCA2 is linked to neoplasm.