PIK3CA and cancer: Moreover, in luminal tumors from very young patients the most frequent cancer drivers are PIK3CA; GATA3, and TP53. In accordance with a recent analysis that included some of these very young patients (≤ 35 years) but mainly older patients, with ages up to 45 years, the most prevalent mutated genes were also PIK3CA, TP53, GATA3 and TTN [49].