We reported previously previously that a cytokine cocktail comprising IL-2, IL-15 and IL-21 selectively increases the population of central/effector memory tumor-reactive tumor-infiltrating lymphocytes (TIL) from pancreatic cancer as well as TIL from WHO grade 4 glioma after ex vivo expansion [21, 22]. Here, IL15 is linked to familial pancreatic carcinoma.