Mesothelin comprises several components: a 36-amino acid (aa)-long signal peptide, (i) the megakaryocyte-potentiating factor (MPF), which is shed into the bloodstream upon enzymatic cleavage (aa 37-286) and (ii) the GPI-anchored mature mesothelin, which is overexpressed in tumor tissues (aa 296-606; with a pro-peptide, aa 607-630, that is cleaved during maturation/activation) [5]. Here, MSLN is linked to neoplasm.