HIF1A and neoplasm: HIF-1α-staining verified hypoxia in central HT1080 and A431 tumor areas (Figure 5E; Supplementary Figure 7A), where vessel wall damage by rhodocetin-αβ was especially prominent (Figure 1E), and abundant composite/ATV/VM vessels were just partially EC-lined (Figure 5E and Supplementary Figure 7A, arrows) or even completely devoid of ECs (Figure 5E and Supplementary Figure 7A, open arrows).