To study the effects of a diminished antioxidant reserve capacity on the susceptibility to myocardial ischemia/reperfusion injury, Nrf2 KO mice were subjected to 30 min occlusion of the left anterior descendent (LAD) artery followed by 24 h of reperfusion, and infarct size and area at risk (AAR) were compared between WT and eNOS KO mice (Figure 2). The gene discussed is NOS3; the disease is myocardial ischemia.