Many studies have found that TBP-2 is overexpressed in patients with T2DM (type II diabetes mellitus) [1], cardiovascular diseases [2], and cataracts [3] and many studies have also shown that TBP-2 expression is decreased in tumor cells [4], such as those caused by colorectal and gastric cancers [5]. The gene discussed is TBPL2; the disease is neoplasm.