Furthermore, MondoA:Mlx not only plays a role in the upregulation of TBP-2 under glucose but is also involved in regulating TBP-2 expression in response to various other metabolic parameters, such as hypoxia [33], lactic acidosis [34], inhibition of oxidative phosphorylation [35], and the presence of molecules that contain adenosine—for example, NADH or ATP [28]. The gene discussed is TBPL2; the disease is lactic acidosis.