According to current research, the downregulated expression of TBP-2 is found in various kinds of human cancer cells, such as those from breast cancer, colon cancer, prostate cancer, bladder cancer, gastrointestinal cancer, lung cancer, malignant pheochromocytomas, high-grade B cell lymphoma, and adult T-cell leukemia (ATL) [4, 5, 42, 45, 46], although TBP-2 was highly expressed in these normal tissues. The gene discussed is TBPL2; the disease is Familial prostate cancer.