And the role of EZH2 in regulating oxidative stress is conflictive in different systems, for example, Yu et al. reported that inhibition of EZH2 against LPS-induced oxidative response in sepsis [37], whereas decreased EZH2 resulted in over-expression of a proapoptotic gene Bim and activation of oxidative reaction in erythroid cells [13]. Here, EZH2 is linked to Sepsis.