A case-control study performed on 90 SCC tumors excised from 73 patients revealed immunohistochemical expression of SP in tumor cell cytoplasm in 81.3% of cases, NK1-R being found in 14% of cases on tumor cell membrane, in 48.3% of cases in infiltrating lymphocytes, and in 22.5% of cases in tumor blood vessels. The gene discussed is TACR1; the disease is neoplasm.