AKT1 and gastric cancer: Fourthly, the analysis of PPI network of targets for HDW against GC indicated the therapeutic effectiveness of HDW in GC possibly owing to its simultaneous regulation of the targets relevant to cell cycle, apoptosis, and angiogenesis, such as CDK2, p27Kip1, cyclin D1, cyclin B1, cyclin A2, p53, AKT1, BCL2, MAPK1, VEGFA, and PIK3CA.