PIK3CA and gastric cancer: Finally, according to the results of GO and KEGG enrichment analyses, the targets regulated by HDW were significantly correlated with multiple biological pathways, namely, NER, apoptosis, cell cycle, PI3K/AKT/mTOR signaling pathway, VEGF signaling pathway, and Ras signaling pathway, which were involved in the primary pathological processes of GC like apoptosis resistance, dysregulated cell cycle, abnormal differentiation, uncontrolled proliferation, migration, and invasion, as well as angiogenesis.