In our previous study, the proteomic response that contributes to the SHR phenotype and reduction of hypertension in LR3-needled rats includes the modulation of seven proteins related to oxidative stress in the medulla oblongata, including SOD, ALDH2, GSTM5, GLUD1, protein DJ-1, Hsp90a, and a-ETF [12]. The gene discussed is GSTM5; the disease is Hypertension.