Obesity rats have increased methylation of the Tsc1 gene promoter and expression of mTORC1, AgRP, and NPY gene and decreased PoMC in the hypothalamus; EA treatment can lower body weight with the extent of body weight decrease being 11.47% and body fat and the body fat rate in DIO rats by demethylation of the Tsc1 gene promoter, decreasing expression of mTORC1, AgRP, and NPY and increasing PoMC. The gene discussed is AGRP; the disease is obesity due to melanocortin 4 receptor deficiency.