In order to investigate the prevalence of the metabolic syndrome after ICSI in adulthood, we performed a comprehensive investigation of the metabolic syndrome and its components, including abdominal circumference, fasting insulin and glucose levels, blood pressure and plasma LDL, and HDL cholesterol levels in the worldwide eldest cohort of adults conceived by ICSI, currently aged between 18 and 20 years. Here, INS is linked to metabolic syndrome.