NLRP3 and stroke disorder: Compared to the sham/vehicle group, the mRNA expression of NLRP3, IL-1β, and caspase-1 was obviously increased in the ischemic core area of the stroke/vehicle group (1.000 ± 0.000 versus 5.024 ± 0.099 for NLRP3, 1.000 ± 0.000 versus 77.070 ± 12.670 for IL-1β, and 1.000 ± 0.000 versus 2.381 ± 0.078 for caspase-1; P < 0.01, P < 0.001, and P < 0.001, resp.; 3 mice per group) (Figure 2(b)).