NLRP3 and brain ischemia: When compared with the vehicle group, MCC950, the NLRP3 inhibitor significantly reduced the neurological deficit score 24 hr after cerebral ischemia reperfusion in diabetic mice (2.545 ± 0.963 versus 3.065 ± 0.629, P < 0.05, n = 22 and 31) (Figure 3).