The influence of tumor cell line and tumor size for the evaluation of PSMA expression was seen in Figure 4, and tumor uptake (% ID) of  68Ga-PSMA-11 increased with tumor anatomical volume (less than 1.0 cm3) in quadratic polynomial fashion while tumor uptake (% ID/cm3) started to decrease when tumor anatomical volume is only 0.5 cm3. This evidence concerns the gene FOLH1 and neoplasm.