The present study reports (a) the preparation, biodegradation, and ultrastructural changes of 32P-CP-PLGA seeds and the biodistribution of 32P-CP particles both systemically and inside the tumour and (b) the anticancer effect on glioma in an animal model after intratumour seeds implantation and therapeutic effect evaluation with integrin αvβ3 receptor targeting radiotracer 68Ga-3PRGD2. Here, CP is linked to glioma.