NOS2 and gastroenteritis: NF-κB proteins are a major family of transcription factors, composed of subunits of the Rel family, p50 and p65 [42], which play a key role in the regulation of proinflammatory gene transcription such as IL-1β, IL-6, TNF-α, Cox-2, iNOS, and adhesion molecules in the process of intestinal inflammation [51, 52].