Nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, a multiprotein complex consisting of NLRP3, apoptosis-associated speck-like protein containing CARD (ASC), and cysteinyl aspartate-specific proteinase-1 (Caspase-1) controlling the release of interleukin-1 beta (IL-1β), is strongly recognized to develop depression [5]. This evidence concerns the gene PYCARD and major depressive disorder.