MR-proADM, a peptide with immune modulating, metabolic, and vasoactive properties [38], has been shown to be an effective prognostic marker in sepsis [39] and septic shock [40] with a comparable and even superior prognostic value for sepsis relative to the conventional inflammatory biomarkers (CRP, PCT, and IL-6), as well as to the disease severity scores (APACHE II and SAPS) [39]. This evidence concerns the gene CRP and Sepsis.