In summary, the LRC cell cycle status in CCS1 tumors is highly plastic, and the population retains the ability to dedifferentiate and proliferate, analogous to the behavior previously described for LRCs in the normal epithelium and also Krt20-differentiated tumor cells’ behavior in vitro (Buczacki et al., 2013; Shimokawa et al., 2017). This evidence concerns the gene KRT20 and neoplasm.