In an alternative study, Shimokawa et al. (2017) show two distinct cell populations exist in human CRCs: a differentiated cell population with limited self-renewal capacity expressing Keratin 20 (Krt20) and a proliferative CSC population expressing Lgr5. Intriguingly, targeting of Lgr5+ CSCs leads to dedifferentiation of the Krt20 population to an Lgr5+ status, sustaining continued tumor growth. This evidence concerns the gene KRT20 and neoplasm.