However, knock-in mice, in which one Myh9 allele has been modified to contain a specific dominant pathogenic Myh9 mutation, R702C, develop defects, including hearing loss and kidney disease, that are similar to symptoms associated with several MYH9-related syndromes such as May-Hegglin anomaly (Suzuki et al., 2013). This evidence concerns the gene MYH9 and macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss.