From the present study, we found that the inflammatory cytokines IL-6 and IL-17 were significantly increased in T cells of RA, knockdown of MiR-128-3p significantly decreased the levels of IL-6 and IL-17, while cells co-transfected with MiR-128-3p inhibitor and si-TNFAIP3 abolished the effects of MiR-128-3p inhibitor, indicating that MiR-128-3p regulated the inflammatory response of RA is through regulating the expression of TNFAIP. Here, IL17A is linked to rheumatoid arthritis.