Based on our results L1RE1 and RARB as well as L1RE1 and RASSF1 might serve as biomarkers for less invasive investigations such as liquid-biopsies or tumor biopsies (e.g., derived by endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA)). The gene discussed is RASSF1; the disease is neoplasm.