LCN2 and myeloproliferative neoplasm: In fact, it has been suggested that normal hematopoiesis is suppressed in MPN by distinct cytokines: lipocalin-2, tumor necrose factor (TNF) β, and TNF-α are aberrantly expressed in MPN and rather interfere with normal hematopoiesis than with the malignant clone [10, 11, 33].