This pathway is crucial to many aspects of cell growth and survival in both physiological as well as in pathological conditions.[40] It has been demonstrated that the PI3K-Akt signaling pathway can be activated by several cytokines such as TNF-α in RA synoviocytes.[41] Moreover, module analysis of the PPI network of OA suggested that the development and progression of OA were related to the Wnt signaling pathway. This evidence concerns the gene AKT1 and rheumatoid arthritis.