AKT1 and rheumatoid arthritis: The majority of DEGs were enriched in a limited number of functional categories, such as “negative regulation of transcription from RNA polymerase promoter,” “nucleoplasm, focal adhesion,” “osteoclast differentiation,” “EMC-receptor interaction,” “MAPK signaling pathway,” and “phosphatidylinositol 3-kinase-protein kinase B (PI3K-Akt) signaling pathway.” Moreover, 160 DEGs were identified between RA and OA samples, including 82 up- and 78 down-regulated DEGs.