Thus, the protective effects of sKlotho in experimental renal failure models [46,50▪▪] may at least partially be explained by a reduction of renal FGF23 resistance, a subsequent reduction of serum FGF23 levels as shown recently by Hu et al. [50▪▪], and, hence, indirect protection against FGF23-induced renal and cardiovascular damage. The gene discussed is FGF23; the disease is acute kidney injury.