For example, NEDD4 degrades the tumour suppressors, such as phosphatase and tensin homologue (PTEN), a lipid phosphatase that hydrolyses PIP3 41 and Beclin 1.42 However, NEDD4 is shown to be dispensable for the PTEN regulation.43 In addition, the oncoproteins such as Ras 44 and Myc 45 are targeted for degradation by NEDD4. The gene discussed is PTEN; the disease is neoplasm.